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Mederma vs Neosporin Reviews - Discover The Best Pick For Scars and Wound Healing!

Posted on 26 April 2018 by

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In this Mederma vs. Neosporin match-up, we will compare and contrast two popular scar products that can be used to minimize the appearance of scars. There is no question, research has clearly shown that the use of certain topical creams and ointments will aid in the healing process (1).

We will analyze the ingredients, effectiveness, and cost of each and tell you who the winner is for scar reduction.

Because both of these products are very different, one being an antibiotic ointment and the other being a topical ointment, we will also provide you with the benefits research has shown will come from the use of each.

If your ultimate goal is to diminish the appearance of the scar, then as soon as the wound is closed, begin using a scar product with silicone in it that has additional ingredients which are absorbable.

To see a list of the Top Scar Creams of 2018 click here.

To begin, we will discuss the ingredients of each product.

Ingredients - Mederma vs. Neosporin

Neosporin Ingredients - There is three active ingredients in Neosporin. As you can see below, each of these ingredients is classified as a First Aid Antibiotic.

The fact that Neosporin's ingredients contain three antibiotics allows for this ointment to be classified as a triple-antibiotic ointment.

There is strong evidence that triple antibiotics like Neosporin are excellent at reducing the time it takes for wound healing (2).

In fact, triple antibiotic ointments, including Neosporin have been clinically shown to improve the general appearance of the wound in within 7-18 days of use versus no ointment (3). 

Active ingredients (in each gram)


Bacitracin 400 units

First aid antibiotic

Neomycin 3.5 mg

First aid antibiotic

Polymyxin B 5,000 units

First aid antibiotic

Mederma Ingredients

Unlike Neosporin, Mederma only has one active ingredient, Allantoin, or onion extract. Allantoin contains a number of antioxidant and anti-inflammatory compounds. Research suggests that Mederma improves the appearance, signs and symptoms of the healed scar versus no treatment (4 , 5).  

In fact, multiple studies have shown that allantoin generally improves scar condition (6). 

Neosporin vs. Mederma, Which Costs More?

The following are listed prices for Mederma and Neopsporin at various retail and online stores at the time this article was published:

Neosporin Prices

  1. Neosporin CVS - $5.00
  2. Neosporin Amazon - $3.97
  3. Neosporin Walmart - $3.97
  4. Neosporin Target - $3.99

Mederma Prices

The price of Mederma was exactly the same at the four below retailers.

  1. Mederma CVS - $14.69
  2. Mederma Amazon - $14.69
  3. Mederma Walmart - $14.69
  4. Mederma Target - $14.69

It is very clear to see from the Mederma and Neosporin prices that Neosporin is much less expensive than Mederma.

In fact, Mederma is more than three times the cost of Neosporin. Is Mederma worth the price?

There is no research to support that Mederma actually works better than Neosporin.

Thus, as far as cost goes, Neosporin is the winner. For our overall winner read below.

Which Scar Ointment Is The Best Choice, Mederma or Neosporin?

As you can see, research suggests that both of these products, Neosporin and Mederma improve the scar condition.

But that isn't the end of the story here, because as we mentioned at the outset, these are two very different ointments.

One is an antibiotic ointment while the other is not. If you are prone to infection, or the area where the wound is located is particularly susceptible to infection, then Neosporin will be the obvious choice.

If, however, the wound is in a good location and you are not susceptible to infection, then Mederma may be the best option for you.

***It is important to remember that both of these products can cause an allergic reaction and contact dermatitis.

So be sure to test it out on an area of the skin before application.

Overall, we are just not convinced that Mederma is worth the difference in cost. Plus, with Neosporin you have the added benefit of infection-fighting ingredients, three to be exact.

In our opinion, this places Neosporin well ahead of Mederma in our battle of the scar ointments.

Do not stop there though…If you have not picked your scar cream for after the wound heals, which is usually a week or two after injury, then take a look at our comparison report for The Best Scar Creams of 2018.

Please be kind and rate this post 😀

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